Conclusion

The LeuBAT complexes allow us to map crucial subsites in the primary binding site that are responsible for binding diverse antidepressants in terms of SSRIs, SNRIs and TCA. With the study of the structure of the complexes it was discovered that inhibitors act by binding to the outwards-open conformation of the transporter.
This information is very important in the development of antidepressants and also helps us understand better how the neurological system works.